动物实验,创伤性脑损伤 z-bo 2020-09-14 407

　　According to a recent study published in the Journal of Neuroscience, targeting overactive immune cells and reducing their chronic neurotoxic effects may provide a new treatment strategy for traumatic brain injury (TBI).

　　This research was done by scientists from Trinity College Dublin and the University of Maryland School of Medicine. Studies have also shown that the effects of TBI on brain degeneration may be changeable after the trauma lasts for a long time. This conflicts with the previous research conclusions.

　　Brain trauma can cause microglia (the immune cells of the brain) to enter an inflammatory state, which is believed to help protect brain function. However, similar reactions are observed in TBI-related neurodegenerative diseases (such as chronic traumatic encephalopathy and Alzheimer's disease). Therefore, long-term inflammation after TBI may lead to neurological degeneration and cognition Decrease in ability.

　　In the new study, scientists have discovered that targeting chronic inflammation pathways may be a very effective treatment strategy for TBI. One month after TBI, the research team used drugs to inhibit the activity of specific receptors on the surface of microglia, thereby killing 95% of mouse microglia. Once the inhibition stops, the cells will rebound back to normal levels. Through a week of "temporary" inhibition, the life span of mice has been significantly extended. The authors found that this inhibitory effect essentially caused the reset of microglia in the mouse brain, that is, the new cells are in a normal state without inflammation. Compared with mice that did not receive drug treatment, mice that received inhibitory treatment had better recovery, lower brain damage, neuronal death, and significantly improved motor and cognitive abilities.