阿尔兹海默症 z-bo 2020-09-15 349

　　Researcher Lei Hongxing and his research team at the Key Laboratory of Genomics Science and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, and his research team have made phased progress in the study of Alzheimer's disease [Alzheimer's disease (AD)] brain stability disorders. A comprehensive investigation of AD brain transcriptome data has screened out 100 high-frequency dysregulated genes, and verified their perturbation in several independent data sets.

　　The top 100 high-frequency dysregulated genes screened out based on AD brain transcriptome data. The perturbation status of each gene in the four main data sets is given by the color bar below the gene ID (red means up-regulation, green means down-regulation, yellow means mixed disturbance, and gray means no change). The 100 genes selected are marked in light green, and other relevant and important genes are also added to the diagram to enhance the functional connection.

　　The treatment and prevention of AD requires a further understanding of its pathogenic mechanism, and the patient's brain transcriptome information reflects the pathogenesis of AD to a certain extent at the level of gene expression. Although thousands of genes have been reported to be dysregulated in the brain tissue of AD in existing studies, the consistency and differences between these studies have not been carefully tested.

　　To this end, researcher Lei Hongxing and his research team conducted a comprehensive investigation of brain transcriptome data for AD and other neurological diseases. The researchers first proved that the frequency of dysregulated genes in AD is highly correlated with its reproducibility. Based on this conclusion, they selected 100 high-frequency dysregulated genes to show the core disturbances in the AD brain, and the disturbances of these dysregulated genes have been verified in several independent AD data sets.

　　On this basis, the researchers examined 12 genes that are highly related to the disease process at the gene expression level. The relevance of these genes to disease processes has been well verified in an independent data set.

　　At the same time, researchers have also discovered an interesting separation of these 100 dysregulated genes in the less infected areas of the visual cortex, which may be a major protective mechanism in these areas. In addition, the researchers also provided the main functions of some transcriptional regulators (such as ZFP36L1).

　　In order to facilitate research in this field, Researcher Lei Hongxing and his research team have also developed an open web server AlzBIG to display the corresponding research information.

　　Researcher Lei Hongxing has been engaged in AD research for many years, and he has made a series of advances in this field before, including AD pathogenesis system biology research, AD pathogenesis system biological network research, AD blood transcriptome characteristic perturbation research And AD chromosome region research, his related work has played a positive role in the research of the pathogenesis of AD, has a high value for the early diagnosis of AD, and provides a theoretical basis for the design of more effective AD drugs.