动物实验,糖尿病 z-bo 2020-09-15 350

　　Grizzlies gain a lot of weight before hibernation, or they are very obese, but they can still maintain insulin sensitivity and do not suffer from diabetes. However, obese humans have a very high chance of developing diabetes. What is the reason? Scientists recently revealed this secret. It turns out that a gene in grizzly bear fat cells is selectively turned off. The protein encoded by this gene is PTEN. People who lack this gene are prone to cancer, but they are not prone to diabetes. Of course, we cannot pay the price of cancer in order to reduce diabetes. Scientists believe that only need to specifically turn off this gene in fat cells to achieve the goal. This research brings new ideas to the treatment of diabetes. The research paper was recently published in the journal Cell Metabolism.

　　Scientists have known for a long time that obese grizzly bears have normal metabolic functions, but the specific reasons have not been known. Kevin Corbit, a scientist at Amgen, California, decided to explore this secret. He and scientists at the Bear Research Center of Washington State University collected blood and other specimens of grizzly bears in different periods of hibernation and analyzed metabolic data such as blood sugar, insulin, and weight. They found that these obese people Grizzly bears will not have metabolic problems even if they gain more than 100 pounds in autumn. Their cells have high insulin sensitivity. If they are humans, they will obviously develop insulin resistance. Scientists have never described such detailed metabolic characteristics of grizzly bears in the past. Subsequent analysis of the blood, liver and fat cells of these grizzly bears found that the cause of this special function was that the PTEN gene was turned off. This may be a new way for humans to deal with diabetes.