中风患者,干细胞疗法 z-bo 2020-09-15 424

　　Stem cells are extracted from the bone marrow of patients to treat stroke. In the first human experiment, this treatment has achieved the expected results.

　　In a previous study, a doctor from the Medical Foundation of Imperial College London and a scientist from Imperial College London treated five patients. In the end, it was found that this treatment was safe, and all patients who received the treatment showed clinical improvements in physical function.

　　The results of this study were published in the journal Stem Cell Translational Medicine. This is also the first human experiment in the UK to use stem cells to treat severe strokes. This treatment uses a type of cell called CD34+. This is a group of bone marrow stem cells that differentiate into blood stem cells and vascular endothelial cells. Previous studies have conducted experiments on animals, and the results have shown that treatment with these cells can reduce the symptoms of stroke. It is not the injected cells themselves, but the chemicals they release that may cause the regeneration of new brain tissue and new blood vessels in the area damaged by the stroke. Compared with other stem cell treatments that require more than 6 months, with this type of treatment, patients with severe stroke can be cured within 7 days. In this study, four-fifths of patients had severe strokes, but only 4% of such patients survived 6 months after the onset of the disease and were able to return to self-care. But what is exciting is that four patients survived the treatment, and three patients were taken care of after six months of treatment.

　　Dr. Soma Banaghi, the lead author and corresponding author of this article, the Imperial Medical Foundation Stroke Medical Advisory College, said: "This study shows the safety and feasibility of this therapy for early stroke patients. Improving the patient's condition in the trial has given us A lot of encouragement, but the conclusion is. It’s too early to get out of the car and more tests are needed to conduct large-scale trials. In the UK, more than 150,000 people suffer from stroke each year. Survivors will suffer mental and physical trauma, among them Many people will not be able to take care of themselves. Stem cell therapy is considered a new type of stroke treatment with full potential. However, its role is still lacking a clear definition. Paul Bent, a graduate of Imperial University Medical School in London, and the lead author of this paper Dr. Lee said: "Using minimally invasive technology. This is the first time that stem cells have been isolated from human bone marrow and injected directly into the injured brain. Currently, the team is using brain scanning technology to monitor the effects of the newly injected cells. "

　　Researchers and key members of the Department of Cancer Surgery at Imperial University said: “These are early data, but they are valuable and worth studying. The scientific data in our laboratory supports clinical results. Our goal is to develop a stem cell-based The secreted drugs and making them available from the pharmacy for most of the identified patients will significantly reduce the treatment time. And the treatment process has been optimized."