细胞培育 z-bo 2020-09-15 351

　　The University of Edinburgh in the United Kingdom recently issued a news stating that researchers have successfully used cell recombination technology to cultivate fully functional thymus using laboratory-grown cells. This is the first time that scientists have used in vitro cells to cultivate complete biological organs, which is essential for the development of new treatments for diseases with weakened immune functions. In this study, the researchers first extracted fibroblasts from mouse embryos, and then used cell recombination technology to transform them into completely different types of cells. Recombinant cells not only look the same as thymocytes, but they also have the ability to support T cell development. Then, when the recombinant cells were mixed with other thymocytes and transplanted into mice, these cells finally successfully developed into biological organs with the same structure and function as the mature thymus.

　　The article stated that this is the first time that scientists have used cell recombination technology to use in vitro cell culture complete living organisms.

　　" Claire Blackburn, a professor at the MRC Regenerative Medicine Center at the University of Edinburgh, said: "Our research has taken a very important step towards the goal of cultivating artificial thymus for clinical use. Yes, the thymus is an important lymphatic organ in the body and is vital to the immune system because it is located near the heart and can produce T cells that fight infection. The main treatment for thoracic disease is to inject immune cells into the body or transplant the thymus immediately after birth, but these treatments are not common due to insufficient donors and matching problems. This new discovery by the University of Edinburgh is expected to change this dilemma. The researchers pointed out that the safe and controlled use of this study is a clinical result, but it is for newborns with thoracic dysplasia or age-related genetic effects of the thymus. Regardless of whether the elderly population is shrinking rapidly, the elderly can benefit from it. In addition, the new therapy may help to quickly rebuild the immune system after bone marrow transplantation, which can also benefit patients receiving bone marrow transplants.

　　This is the first time that scientists have used cell recombination technology to cultivate complete living organisms with in vitro cells.