miRNA,幽门螺杆菌 z-bo 2020-09-16 389

　　The close relationship between Helicobacter pylori and gastric cancer has been confirmed by a large number of studies. A research team from the University of Tokyo in Japan published a paper in the new issue of "Nature-Communications", claiming that they discovered that a small ribonucleic acid plays a key role in gastric cancer caused by Helicobacter pylori infection.

　　This achievement has promoted the understanding of the pathogenesis of the stomach and will help to understand the mechanism of Helicobacter pylori-induced inflammation and the cause of gastric cancer.

　　Helicobacter pylori is a single-stage, flagellar, spirally curved bacteria. Infection with this bacteria can cause inflammation in the stomach, leading to gastritis, gastric ulcer and gastric cancer. However, the detailed mechanism by which it induces abnormal cell proliferation has not been clarified.

　　small ribonucleic acid is a type of single-stranded ribonucleic acid molecule that does not code for protein production. It is mainly involved in controlling gene expression and regulating the functions of various genes. Researchers at the University of Tokyo Medical Research Institute infected gerbils with Helicobacter pylori. About two months later, they collected the gastric epithelial cells of gerbils. They investigated the expression of small ribonucleic acid and found a kind of miR-210. The expression of small ribonucleic acid was significantly reduced.

　　After investigating the function of miR-210, the researchers found that after its expression in gastric epithelial cells, cell proliferation was suppressed, but suppressing its expression would promote cell proliferation. Researchers plan to use more sophisticated analysis to understand how Helicobacter pylori affects the expression of miR-210, and contribute to the use of this small ribonucleic acid for gastric cancer detection and treatment.