糖尿病基因 z-bo 2020-09-16 378

　　On the same day, researchers from the Swiss Federal Institute of Technology Lausanne and the Swiss Federal Institute of Technology Zurich found through their research that humans and mice share the diabetes gene. Related research was published in the international journal Cell Metabolism.

　　In the article, the researchers conducted genome and phenotype studies on 183 mice. Researcher Johan Auwerx said that the effects of environmental factors can be assessed by comparing the metabolic status of twin mice with different growth and diet conditions. Its effect on the expression of certain genes in the body provides specific data to clarify the clinical characteristics of mice and their impact on disease development. Combining genotype and phenotype research can significantly speed up scientific research. In this study, we added a new quality analysis technology based on genotype and phenotype analysis. Thousands of proteins in the samples were quantified and a special proteomics database was established. The researchers combined the relevant data of mouse genome, phenotype, proteome and metabolomics, and discovered a special gene on mouse chromosome 2, which is related to type 2 diabetes. The important role of diabetes depends on gene expression.

　　By combining multiple levels of data, researchers have clearly classified the relationship between whether genes are turned on and diabetes risk. Further studies have shown that the content of a special metabolite 2-aminosuccinic acid in the urine of diabetic mice is very low, and its concentration changes obviously depend on the existence of this special gene, but it depends on the mice. It turns out that it has nothing to do with fat. The researchers pointed out whether this relationship also exists in mice, so they conducted another study on diabetic patients. As a result, the level of 2-aminooxalic acid in diabetic patients did not exist. Because it is lower than in diabetic patients, the metabolite 2-aminosuccinic acid in urine can be used to help detect whether a person has diabetes. The research in this article may help scientists develop new diagnostic tools for diabetes and other diseases.