白血球,皮肤细胞 z-bo 2020-09-16 352

　　For the first time, American scientists have used simple methods to turn human skin cells into transplantable white blood cells. As we all know, white blood cells are the "guard" of the immune system and can help the body resist infection and invaders. Researchers say that the latest research helps them devise treatments to introduce new white blood cells into the body to deal with cancer or other diseases. Related research results were published in the latest issue of "Stem Cell Journal".

　　One of the authors of the paper, Juan Carlos Luzpizua-Belmot of the Salk Institute for Biological Research in California, said: “Studies on rats have shown that this process is fast and safe, and that this The method circumvents long-standing obstacles in reorganizing human cells for therapeutic and regenerative purposes."

　　Blood cells produced by induced pluripotent stem cells (iPS) often cannot be implanted in organs or bone marrow, and they may also cause tumors. The new technology developed by researchers called "indirect lineage transformation" takes only two times. Zhou also does not generate tumors. At the same time, previous studies have shown that this new technology can be used to generate human blood vessel cells.

　　The lead author of the study and researcher at the Salk Institute, Ignacio Sancho Martinez, said: “We did not return skin cells to the state of stem cells, but used new technology to make skin cells forget that they were What, and then let it be transformed into the cell type we need. In the latest research, we have successfully transformed it into white blood cells. Moreover, it takes only two organisms to induce the cell to lose memory and guide it to "transform" into a new cell. molecular."

　　In the latest research, scientists have borrowed new technology to make a molecule called SOX2 plastic, which means it loses its memory of being a special cell type. Subsequently, the researchers let a genetic factor called miRNA125b, Induces cells to transform into white blood cells.

　　Currently, researchers are conducting research on toxicology, cell transplantation, pre-clinical research and proof-of-concept before clinical research. They said that the latest research has taken them one step closer to the use of stem cell transplantation to treat human diseases.