帕金森氏病 z-bo 2020-09-16 342

　　Recently, neuroscience researchers applied advanced computer models to obtain information about the multiphase process that caused Parkinson's disease. This research was published in the journal Neuroscience. The typical manifestation of Parkinson's disease is slow movement, body aches and a series of symptoms such as body trembling. At present, there is no suitable drug to treat Parkinson's disease, so it is very necessary to use new methods to study the disease. Research investigations show that this central nervous system disease has affected the lives of one thousandth of Danes.

　　Dopamine is an important neurotransmitter that affects physical and mental functions. The physical and mental functions affected include motor control, learning and memory functions. The level and use of these functions are adjusted by special dopamine cells. When the level of dopamine decreases, nerve cells, the component of the brain's "stop signal", are activated.

　　This stop signal is like an electric lawn mower with a safety bar: if your hands leave the safety bar, the lawn mower engine will stop. Similarly, dopamine must be present in the nervous system at all times to prevent the "stop signal" from being activated. Part of the cause of Parkinson's disease is that dopamine cells are lost in the brain, which causes the "stop signal" to be activated. Therefore, many researchers believe that long-term lack of dopamine will inevitably cause some typical clinical symptoms of Parkinson's disease.

　　a tricky question

　　"By scanning the brains of Parkinson's patients, we have observed that although the dopamine cells have died, there is no sign of lack of dopamine cells, even in the late stage of the disease. There is no evidence of Parkinson's disease so far. In the case of resurrecting dead dopamine cells in his body, so far researchers have not been able to solve this problem. On the one hand, the patient’s symptoms indicate that the "stop signal" has been activated, but the patient has received corresponding treatment and has a certain effect On the other hand, computer data shows that they are not deficient in dopamine." Jakob Kisbye Dreyer said.

　　Calculation and model prediction of disease progression

　　Calculations show that cell death only affects dopamine levels in the late stage of onset, but the symptoms caused by Parkinson's disease will appear early before the neurotransmitter declines, because the normal fluctuating signal has been weakened before the neurotransmitter declines. In the computer model, the brain compensates for the missing signal by creating additional dopamine receptors. This will initially have a good result, but the correction signal may slowly disappear when the cell death becomes more severe. Often at this stage, brain compensation is so indispensable that a small change in dopamine will trigger the "stop signal" to be activated, thus causing the patient to cause disease.