艾滋病病毒,HIV z-bo 2020-09-16 328

　　It was learned from the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences that the basic immune innovation group led by researcher Zheng Yonghui of the Natural Immunity Joint Laboratory has discovered a new way to inhibit the synthesis of HIV envelope protein. This research has opened up a new direction for the development of AIDS vaccines and anti-AIDS drugs. Related research results were recently published in the American academic journal "Journal of Virology".

　　According to Zheng Yonghui, most animal viruses, including those that can cause severe diseases such as AIDS, influenza, Japanese encephalitis, hepatitis C, severe acute respiratory syndrome, Ebola hemorrhagic fever, and dengue fever, are outside the virus particles. There is an envelope containing glycoproteins. These glycoproteins are also called envelope proteins, and viruses infect target cells by recognizing these glycoproteins.

　　The development of an AIDS vaccine is a worldwide problem. One of the difficulties is that it is difficult to efficiently express the HIV envelope protein in mammalian cells. In the 1980s, American scientists discovered that in HIV-infected cells, only 15% of the viral envelope protein can be expressed, and most of the rest are retained in the endoplasmic reticulum by an unclear mechanism. Degraded.

　　A few days ago, Zheng Yonghui's team made significant progress in this research field. They studied a human T cell that was not infected by HIV and found that the cell overexpressed a protein called TSPO and caused the degradation of the viral envelope protein. In-depth study of the function of TSPO protein by targeted gene knockout technology, and found that down-regulating the expression of TSPO in cells can increase the synthesis of viral envelope protein, while up-regulating the expression of TSPO can inhibit the synthesis of viral envelope protein, so as to achieve resistance The purpose of virus infection.

　　Zheng Yonghui said that the results of this study can not only provide clues to explain the mechanism that HIV envelope protein cannot be expressed efficiently, but also clarify a new type of antiviral mechanism.