抗伤寒基因 z-bo 2020-09-17 354

　　Recently, in a research report published in the international journal Nature Genetics, researchers from the University of Melbourne discovered a gene mutation that has five times the effectiveness of fighting typhoid fever. Typhoid fever can cause millions of deaths every year.

　　In the article, researchers screened and analyzed the genomes of millions of typhoid fever-infected individuals and healthy individuals in Vietnam and Nepal. The relevant research results may help develop new vaccines against typhoid fever and other bacterial diseases. Researcher Professor Sarah Dunstan said that we have discovered a special form of gene called HLA-DRB1 that may help individuals resist typhoid fever in their natural state.

　　According to data from the World Health Organization, approximately 21 million people are infected with typhoid fever each year, and approximately 216,000 to 600,000 people die from the disease. Typhoid fever is caused by individuals infected with Salmonella typhi and Salmonella paratyphi in contaminated food and water; the new genes discovered by researchers can protect the body from infection by identifying the special proteins of invading bacteria. There are currently anti-Salmonella typhi Vaccine, but it is not always effective, and it is not suitable for vaccinating young children. Therefore, the development of a typhoid vaccine for a wide range of people is urgent.

　　Finally, the researchers said that it is worth noting that there is currently no approved vaccine against Salmonella paratyphi causing enteric fever, and the incidence of infections caused by Salmonella paratyphi is increasing in Asia, and this article studies It is very important to develop a new vaccine against typhoid fever. The researchers said that they will use more in-depth research to promote the development of new vaccines to a higher level.