中风基因,PHACTR1 z-bo 2020-09-17 417

　　Stroke (Stroke) is the scientific name for cerebral apoplexy, which is a disorder of cerebral blood circulation that starts suddenly. Also called a cerebrovascular accident. Refers to patients with cerebrovascular disease, due to various predisposing factors that cause intracerebral artery stenosis, occlusion or rupture, which causes acute cerebral blood circulation disorders, clinically manifested as symptoms and signs of one-time or permanent brain dysfunction. Stroke is divided into ischemic stroke and hemorrhagic stroke.

　　Researchers from Royal Holloway, University of London and an international research team from the United States and Europe analyzed the genes of 1,400 stroke patients and 14,400 normal patients due to rupture of an intracerebral artery, and found that the PHACTR1 gene protects people One of the main reasons to avoid stroke (Stroke).

　　gene PHACTR1 is to maintain the integrity and function of blood vessels. Scientists have recently discovered that a gene mutation called PHACTR1 can reduce the risk of acute cerebral blood circulation caused by carotid artery rupture. This study can find new treatments for young and middle-aged people in advance to prevent stroke.

　　The results of the study were published in the journal Nature Genetics. PHACTR1 is the main cause of stroke in young people. This study may provide a basis for new treatment and prevention of strokes and other diseases. The same gene variant has also been identified as a protector against migraine and heart attack.

　　Professor Pankaj Sharma, School of Biological Sciences, Royal Holloway College, said: "This is an important breakthrough that allows us to further understand the relationship between the genome and key vascular functions, and can help new therapies for some difficult and complicated diseases related to vascular diseases. .

　　Professor Sharma added: “It will further cooperate with various institutions around the world in the future, hoping to further explain the underlying mechanism between genes and stroke. The Bio-Repository of DNA in Stroke (BRAINS) project that he is studying has been formed. A large-scale DNA biobank for stroke has been established, which will provide conditions for identifying more directly related genes."