驱虫药 z-bo 2020-09-17 387

　　Anthelmintics and antihypertensive drugs are far from each other. A research team from Tokyo Medical and Dental University and Keio University announced that they have confirmed in animal experiments that a deworming drug for sheep and cattle has a lowering effect. Pressure effect.

　　There are more than 7 million hypertensive patients in Japan. Although most people suffer from the disease without a single cause, excessive salt intake is considered to be one of the causes of high blood pressure in Japan.

　　The research team led by Professor Shinichi Uchida of Tokyo Medical and Dental University noticed that an enzyme called SPAK kinase plays a role in recovering the necessary salt into the body when the kidneys produce urine. When this enzyme is active, the excretion of salt through urine will be blocked, and the body will become too salty.

　　When the research team investigated compounds that can inhibit the action of this enzyme from about 900 existing drugs, they found that closantheil, which repels animal parasites, has the above-mentioned effects. After 30 minutes of injecting closentyre into the abdomen of the experimental mouse, the blood pressure of the experimental mouse began to decrease, and the effect could last about 2 hours.

　　Until now, therapeutic drugs inhibit SPAK kinase by interfering with the function of adenosine triphosphate, which is an energy source for life activities. Therefore, it is difficult to target SPAK kinase only.

　　In the future, the research team plans to change the molecular structure of closentyre and develop effects.