The research was conducted by a research team led by Professor Yashiro Tsukamoto of Kyoto Prefecture University. Among the highly pathogenic avian influenza viruses reported, the AH5N1 virus is extremely virulent and can infect humans. Generally speaking, after a chicken is infected with this virus, it will not become weak and die immediately like other diseases.
When the research team used chickens to conduct H5N1 virus infection experiments in Indonesia, they found that blood vessels in the chicken organs showed symptoms of bleeding and congestion. The analysis of their chicken lungs showed that in the pressurized substance, the content of endocrine bases was about 3 times higher than the normal level, and the content of endorphin receptors was about 1.5 times higher than the normal level.
The research team believes that abnormal amounts of endocrine can cause rapid bleeding and ischemia, leading to rapid death of chickens. After injection of chicken embryo protein and inhibitors that prevent the recipient from functioning in chickens, the fatality rate dropped from 100% to about 20% 5 days after infection. However, the mechanism by which endocrine proteins and receptors increase after viral infection is still unclear.
The research team believes that bleeding disorders (such as Ebola hemorrhagic fever) also require the same mechanism. Tsukamoto said: "In the treatment of human Ebola hemorrhagic fever, endoglin and receptor inhibitors may be used as therapeutic agents."