帕金森氏病 z-bo 2020-09-17 324

　　Recently, it was learned from the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences that for the first time, Liping Wang’s research group discovered that specific activation of glial cells can promote stem cell differentiation and repair damaged brain tissues in Parkinson’s disease, which is expected to explore the pathogenesis of Parkinson’s disease. And treatment brings new hope.

　　It is understood that the prevalence of Parkinson's disease in the elderly population over 60 years old in China is 1% to 2%, and it is increasing every year and tends to be younger. Traditional drug treatment methods will develop resistance along with the development of the disease, and increasing the dose will have greater side effects on the body. However, the application of stem cells to the treatment of Parkinson's disease is still inconclusive. This is mainly because the transplanted stem cells are transformed into neurons with specific functions in the body and are affected by many factors.

　　Wang Liping’s group used optogenetic technology to integrate electrophysiology and molecular biotechnology, and for the first time discovered that specific activation of glial cells can release growth factors, which play an important role in protecting dopaminergic neuron function, and then achieve the repair of Parkinson’s disease. The purpose of impairing brain function.

　　The results further confirmed the important function of glial cells in stem cell differentiation and repair of neural circuits, and provided a new research approach for the application of optogenetics technology to analyze the complex network of neurons, glial cells and stem cells in the brain. The research and treatment of Parkinson's disease provide possible new targets, as well as new ideas for the pathogenesis and treatment mechanisms of other neuropsychiatric diseases.