遗传编码,调控血糖 z-bo 2020-09-17 351

　　Physiological tools for sequential control of gene expression and cell functions to clarify the process of physiological activity are invaluable, and even have prospects for specific clinical therapeutic applications.

　　A recent research paper reported a new genetic code system that can be remotely controlled by low-frequency radio waves or magnetic fields. First, the heavy and light chains of ferritin labeled with green fluorescent protein are fused to form ferritin nanoparticles containing iron oxide as the intracellular core. Then, the ferritin nanoparticles interact with the anti-green fluorescent protein transient receptor potential vanilloid 1 to form a fusion protein (aGFP-TRPV1).

　　Existing knowledge shows that transient receptor potential vanillic acid 1 (TRPV1) is a temperature-sensitive ion channel that can be opened when the temperature rises. Therefore, when the aforementioned fusion protein is formed, the iron oxide contained therein receives non-invasive radio wave or magnetic field signals and generates heat, thereby activating ion channels. Through cell and mouse experiments, the researchers proved that TRPV1 has the ability to convert these force field signals with the help of iron oxide. The opening of ion channels leads to the activation of calcium-dependent gene transcription. When the genetic element encoding the insulin gene is transferred to the mouse using a stem cell or viral expression system, the signal is emitted by radio waves or a magnetic field, thereby triggering the transcriptional expression of the insulin gene in the mouse accordingly. I lowered my blood sugar level.

　　Finally, this powerful and reproducible remote control method in vivo can be applied to basic scientific research, engineering research and clinical treatment to create human well-being.