艾滋病,HIV z-bo 2020-09-18 305

　　A new drug tested in monkeys provides an amazing defense against the animal version of HIV. This is a major advance in the exploration of an AIDS vaccine.

　　According to a report by Agence France-Presse on February 18, these scientists reported in the journal Nature that rhesus monkeys using this drug can resist repeated high-dose injections of monkey immunodeficiency virus.

　　The leader of the study, Michael Falzan, a professor at the Scripps Research Institute in Florida, said: "We...show a way to obtain long-term vaccine-like protection against HIV-1. "HIV-1 is the main type of human AIDS virus.

　　"This prototype drug called eCD4-Ig consists of two mock receptors or docking points, through which HIV attaches to the important immune cells CD4 cells.

　　The simulated receptor catches the virus and tricks it into starting the docking procedure in advance. The virus can only perform a docking procedure once, so it can no longer attach to CD4 cells.

　　Falzan said that they compared this effect to closing the door in front of an intruder and then throwing away the key. He said the drug can provide "extremely strong protection."

　　Their paper reports on a 40-week experiment. Experiments have shown that the inoculated rhesus monkeys were safe even after being injected with 4 times the infection dose of HIV in the control group.

　　Falzan said that further research found that the treated rhesus monkeys "can still resist 8 or even 16 times the infection dose of HIV after more than a year of vaccination."

　　In the fight against AIDS, vaccine research has always been the most frustrating chapter.

　　Traditional antibody-based vaccines can only provide partial protection, partly because HIV mutates.

　　This new formula targets the so-called "very conservative" Env protein of HIV-"conservative" is a scientific term that means these positions are not so easy to mutate.

　　Tests in laboratory containers also found that the drug is also effective against human HIV, which is very close to the monkey immunodeficiency virus.

　　Falzan said: "Unlike antibodies, our protein is effective against all types of HIV tested, so it may lead to an effective AIDS vaccine that can replace antibodies."