阿尔茨海默病,老年痴呆症,依达拉奉 z-bo 2020-09-18 461

      According to reports, edaravone can be used to treat thrombotic stroke Darabon (Darabon), which can effectively prevent and treat Alzheimer's disease (AD). AD is a neurodegenerative disease characterized by progressive and irreversible memory loss and cognitive dysfunction, and is the most common type of dementia. At present, there are approximately 36.5 million AD patients in the world, and it is estimated that there will be more than 100 million by 2050, which makes it an important health problem facing the world. However, there is currently no way to prevent or slow down the progression of the disease. Amyloid β (Aβ) is considered an important pathogenic substance of AD. In the past two decades, clinical trials of Aβ have been unsuccessful, partly because there is a single intervention target. Due to the complex pathological mechanism of AD, effective prevention and treatment of AD needs to be a comprehensive intervention of multiple targets or multiple pathological links of its pathological mechanism. Professor Wang Yanjiang’s research team recently conducted a comprehensive study on the prevention and treatment of AD. "Nature Review" neurology suggests that the prevention and treatment of AD should be comprehensively intervened at different stages of the disease according to different pathological mechanisms (http: euro.Dxy.cn/article). /71055). Edarabon is a kind of oxygen free radical scavenger, which is commonly used clinically to treat acute ischemic stroke. Oxidative stress is also an important cause of AD. Professor Wang Yanjiang’s research team and collaborators found that edaravone can not only antagonize oxidative stress, but also directly act on the β-sheet formation site of Aβ, thereby inhibiting the deposition of Aβ. Through long-term injection or oral administration of edaraben, Aβ deposition in the brain of AD mice effectively reduces the level of oxidative stress in the brain tissue, inhibits Aβ production and tau protein phosphorylation, and greatly improves the cognitive function of AD mice.

　　 This study shows that edaravone has a comprehensive therapeutic effect on multiple important pathological links of AD. As the current research and development of new drugs for the prevention and treatment of AD continue to fail, the discovery of the effect of the existing clinical drug edaraben is expected to become an effective prevention and treatment drug for AD. it has been. According to reports, the research team has started clinical trials using edaraben to prevent and treat AD.