猪瘟病毒 z-bo 2020-09-18 323

　　After years of research, the innovative swine infectious disease research team of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences discovered a new swine fever virus receptor, laminin receptor. This allows researchers to better understand the replication mechanism of hog cholera virus and design specific antiviral strategies for cell receptors. In addition, the discovered cell receptors can be used to reconstruct cell lines suitable for virus growth and reproduction. , Effectively improve the production efficiency of swine fever vaccine. Therefore, the study of cell receptors is very important for the prevention and treatment of swine fever.

　　Swine fever is a major disease that seriously threatens the global pig industry. It has been included in the list of animal diseases that the World Organization for Animal Health (OIE) must declare. In the medium and long-term animal disease prevention and management plan, China has listed it as five key tasks, which is one of the animal diseases that need to be controlled. The cell receptor of the virus is the "gateway" for the virus to invade the host cell. Very important for virus infection. Therefore, blocking the binding of the virus and the host cell receptor can block the invasion and infection of the virus. According to researcher Qiu Huaji, a variety of candidate cell receptor molecules of hog cholera virus have been obtained through analysis and screening of small RNA interference technology. System identification confirmed that one of the laminin receptors is involved in the adsorption of hog cholera virus to cells, and its expression level is closely related to the proliferation ability of hog cholera virus. The protein is pig. A protein that indicates that it is a receptor that mediates the adsorption of cholera virus to host cells. The discovery of a new receptor protein for swine cholera was published in an internationally renowned virology journal.