乙肝慢性化 z-bo 2020-09-18 305

　　The top international academic journal in the field of hepatitis [IF = 11.2] officially published the research paper "Genetic variation infivenovellociincludeCFBandCD40predisposetochronichepatitisB" by Professor Yu Long's research group from the School of Life Sciences, Fudan University. This is the first online publication on 5 to reveal two chronic hepatitis B . An important source of risk.

　　China is the main country for hepatitis B. 120 million people are infected with hepatitis B virus (HBV), of which 30 million have chronic hepatitis B. In recent years, the popularity of neonatal hepatitis B vaccine has greatly reduced the number of new hepatitis B cases. However, there is currently no clear and effective drug that can eliminate the hepatitis B virus in tens of millions of chronic hepatitis B patients, and they will face the risk of developing liver cancer. We hope that systematically elucidating the genetic mechanism of chronic hepatitis B will find drug targets for the treatment and prevention of chronic hepatitis B.

　　The research groups of Professor Yu Long and Professor Xu Jianfeng of the School of Life Sciences of Fudan University have conducted joint research with more than 20 research units and more than 40 scholars. Genome-wide Association Study (GWAS) method analyzed 9114 and 9257 normal controls of chronic hepatitis B patients in five independent populations in the north and south. For the first time, five major risk loci of chronic hepatitis B were identified, including CD40 and CFB. This new discovery has promoted the understanding of the genetic mechanism of chronic hepatitis B virus infection and laid an important foundation for the development of effective treatment and prevention of hepatitis B and liver cancer caused by hepatitis B. Create good conditions for the ultimate goal of reducing morbidity. ..

　　This study is the world's largest and most fruitful genetic study of chronic hepatitis B. The main author of this article is Jiang Deke, associate professor of life sciences at Fudan University. Long Yu and Jianfeng Xu are the main authors of this article. Fudan University is the first and last author of this article.