糖尿病,老年痴呆 z-bo 2020-09-18 370

　　According to foreign media reports, scientists at Washington University School of Medicine in St. Louis said that researchers have discovered a unique link between diabetes and Alzheimer's disease. This provides further evidence that diseases that cause people to lose memory may be affected by hyperglycemia. Many previous studies have shown that diabetes can cause Alzheimer's disease, but this latest study (in mice) shows that high blood sugar can rapidly increase β-amyloid levels. display. Amyloid beta is an important part of the brain plaques in Alzheimer's disease patients. Plaque accumulation is believed to be the early cause of a series of complex brain changes caused by Alzheimer's disease.

　　The report’s lead author, PhD researcher Shannon McCorley, said: “Our findings indicate that diabetes and other diseases that are difficult to control blood sugar levels may have harmful effects on brain function and cause Alzheimer’s disease. This disease is exacerbated. The connection we found will allow us to target treatment in the future to mitigate this impact."

　　The blood sugar level of diabetic patients is not controlled, and the blood sugar level rises after meals. Many patients rely on insulin and other drugs to control blood sugar levels. In order to understand the possible impact of high blood sugar on the risk of Alzheimer's disease, the researchers injected glucose into the blood of mice. The direction of these mice is to develop a disease similar to Alzheimer's disease. In young mice without amyloid plaques in the brain, doubling the blood sugar level increased the level of beta-amyloid in the brain by 20%. when

　　When scientists repeated the experiment in elderly mice that already had brain plaques, β-amyloid levels increased by 40%. Researchers also found that increased blood sugar levels activate more brain neurons, thereby promoting the production of β-amyloid. KATP channels on the surface of brain cells can affect the excitation of such neurons. In the brain, high blood sugar closes these channels, which stimulates brain cells and makes them easier to discharge. Normal excitement is the way brain cells encode and send information. However, excessive excitement in certain areas of the brain will increase the production of β-amyloid, which eventually increases amyloid plaques and accelerates the development of Alzheimer's disease.