HIV-1传播,粒细胞 z-bo 2020-09-19 368

　　A study by Wang Jianhua's research team at the Shanghai Pasteur Institute of the Chinese Academy of Sciences found that human granulocytes have a new function that can promote the spread of HIV-1 infection. Related research findings were recently published in the "Journal of Virology". Different from granulocyte hematopoietic stem cells, granulocytes mainly contain neutrophils, eosinophils and neutrophils, among which neutrophils account for 50% to 60% of white blood cells. Eosinophils and eosinophils account for about 1% and 6%, respectively. Under pathogenic or pathological conditions, granulocytes are mobilized into surrounding tissues and participate in inflammatory reactions. The three types of granulocytes express very few HIV-1 receptor CD4 and co-receptor CXCR4, so they are often ignored in HIV-1 infection research. There are few studies on the role of granulocytes in HIV-1 infection and etiology, but there are reports on the neutrophil dysfunction caused by HIV-1 infection. in

　　Under the guidance of Wang Jianhua, PhD student Eihei and research assistant Jiangjinfeng obtained three types of granules from the peripheral blood of healthy people: eosinophils, basal globules and neutrophils. The spheroids were purified and their interaction with HIV-1 was studied. Studies have shown that none of these three granulocytes can directly infect HIV-1, but they can capture HIV-1 and deliver the captured infectious virus particles to CD4 + T cells for virus transmission. And can promote infection.

　　The research team cooperated with the First Affiliated Hospital of Kunmei Medical University and Kunmei Third People's Hospital, regardless of the continuous loss of CD4 + T cells or the outbreak of opportunistic pathogen infection, there are granulocytes in the blood. The number is greatly reduced. The results of the study show that granulocytes continue to be captured, spread and increase the risk of viral infection, while providing a new strategy for the treatment of HIV-1/AIDS.