动物实验,HIV疫苗 z-bo 2020-09-21 371

　　Scientists have developed enhanced vaccines that can evade existing antibodies in the body, and have provided new ideas for optimizing and improving vaccines (including HIV vaccines). HIV vaccines developed based on this technology have passed animal experiments.

　　The research team of Tang Ruikang, a professor at the Qiushi Advanced Institute of Zhejiang University, Chen Ling, a researcher at the State Key Laboratory of Respiratory Diseases at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, and a researcher at the Institute of Microbial Epidemiology, Academy of Military Medical Sciences, Qin Chengfeng, jointly completed the study.

　　For more than 30 years, the scientific community has conducted initial clinical trials of nearly 200 AIDS vaccines, but most of them ended in failure. Chen Ling believes that "the reasons for failure may include multiple factors, but one of them may be due to the presence of neutralizing antibodies against adenopathy in most humans, which can'neutralize' the adenovirus carrier used as an AIDS vaccine, rendering the vaccine ineffective. ."

　　Scientists have modified the adenovirus vector carrying AIDS antigen. Co-first author, Dr. Wang Xiaoyu, Qiushi Advanced Research Institute of Zhejiang University, said: "We tried to use biomineralization methods to'wear' a layer of calcium phosphate film coat on the vaccine to improve the performance of the vaccine." Known as virus biomimetic mineralization technology. Wang Xiaoyu said: "A vaccine that has been'armed' is like putting the vaccine into a'Trojan horse'. It can effectively evade the defense line of the neutralizing antibody against the adenovirus itself and successfully enter the cell castle." Co-first author , Dr. Sun Caijun of Guangzhou Institute of Biomedicine and Health said that once the vaccine enters the cell castle, under the acidic environment of the lysosome in the body, the vaccine will soon break out of the "Trojan horse" and express the target antigen. Trigger a series of immune responses. Without this coat, the adenovirus vector vaccine is like running streaking in an environment densely packed with anti-adenovirus neutralizing antibodies. Most vaccines cannot express antigens and induce immune responses.