流感病毒 z-bo 2020-09-21 363

　　Recently, the National Institute of Respiratory Diseases, jointly established by Guangzhou Medical University and the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences, discovered that the M2 protein of influenza A virus blocked autophagosomes for the first time in the world through hydrogen ion channel activity. I discovered and confirmed that I would do this, and fusion with lysosomes inhibits an important mechanism of autophagy degradation.

　　According to research, influenza virus infection affects the autophagy process. Influenza virus can cause autophagosome accumulation in vivo and in vitro, but the effect of influenza virus on autophagy and its mechanism are still controversial. The researchers found that the M2 protein prevents the fusion of autophagosomes and lysosomes through its ion channel activity and inhibits autophagy degradation. At the same time, we confirmed that blocking the autophagy of M2 protein does not depend on the Beclin1/PI3Kinase complex signaling pathway. This study further clarified the mechanism of influenza virus in autophagy, and provided important clues for further exploring the mechanism of autophagy mediating inflammatory response and lung injury during influenza virus infection, and it is highly pathogenic through intervention. . Provide important clues for research on reducing sexual behavior. The strategy of excessive inflammatory response and lung damage caused by sexual avian influenza virus infection provides an important basis.