HIV疫苗 z-bo 2020-09-22 317

　　Human immunodeficiency virus is a very diverse virus that can adapt to the individual's own immune response during the infection process. The latest research papers of the University of Alabama and Emory International Journal University in the field of natural medicine found that HIV virus levels help predict the current medical condition of individuals, and the new HIV-1 epidemic is a new host. Through research, I found that it is also applicable. By using a new method to determine how well the virus adapts to the host cell's immune response, researchers can predict the progression of the disease in the patient. The immune response of CD8 + T cells can eliminate HIV-infected cells. These T cells are activated by polypeptide epitopes on the surface of the virus. These polypeptide epitopes are usually human leukocyte antigen proteins on the surface of antigen-presenting cells. Proposer. Human leukocyte antigens are cell surface proteins that show polymorphic changes in the human genome. Some spontaneous mutations in HIV can change epitopes, make human leukocyte antigens ineffective, and cannot stimulate the body to stimulate an immune response. The adaptation process of the body virus continues to occur, and some adaptation processes continue, even if the virus spreads to new types of individuals. In this study, the researchers used a new model to quantify the adaptability of the virus, and the results showed that the virus is highly adaptable to the human immune system, and the immune system is extremely harmful to individuals.

　　Researcher Dr. Jonathan Carlson pointed out that preconditioning can triple the rate of disease development in individuals infected with the virus, mainly due to low CD4 cell count and high viral load. Adaptive viral epitopes are usually not easily recognized by the immune system, but even if the adaptive epitopes are recognized, the body's immune response to killing infected cells is very weak. Therefore, some viruses that can usually induce human immune response are not detected in important parts of the immune system, which creates loopholes in the human immune response process. Dr. Eric Hunter said that if the candidate vaccine cannot produce a functional response to the adaptive epitope of the virus infected in the natural environment, then it may not be able to induce the candidate vaccine to cause a specific immune response in the body; As a result of the AIDS vaccine test, the virus became more suitable for vaccine candidates, and it was found that people who received the vaccine were more likely to be infected with HIV than those who were not vaccinated. Therefore, for researchers, this is a way to develop an effective HIV vaccine. In order to make the human immune system respond to the vaccine, researchers need to consider the immune system's response to adaptive HIV. Have. The ideal vaccine for AIDS can induce antibody production and cause cellular immune response. Over the past decade, the number of HIV infections in the United States has declined, but there are 50,000 new infections each year. Effective AIDS treatment methods have been used for nearly 20 years, but it seems that the development of more effective suppression therapies can actually curb the increase in HIV-infected patients.