Y染色体丢失,阿尔茨海默病 z-bo 2020-09-22 375

　　The loss of the Y chromosome in blood cells has evolved into a biological explanation. Why is the life expectancy of men shorter than that of women? Researchers published a research report in the American Journal of Human Genetics. In this report, male blood samples The loss of the Y chromosome leads to Alzheimer's disease, and people with this disease promote it best. It has been proven that people with this gene have the same risk of this disease. The results of this study will be presented at the annual meeting of the European Society of Genetics. Las Forceberg, a researcher in immunology, genetics and pathology at Upsara University in Sweden, said: Yes, but what we are looking for are the mating mutations we get in our daily lives. Jan Dumansky, the first author of the study, said: To be precise, the mating mutations found in living male cells are some loss of Y chromosomes in blood cells. The incidence of Y chromosome loss in men is as high as 17%, and the elderly and smoking men tend to have Y chromosome loss. This study expanded the following point: Y chromosome loss is a well-known high risk factor for cancer (10.1038/ng.2966). This research can also be used as a predictor of various harmful health outcomes. This is Alzheimer's disease. It is not clear why the loss of the Y chromosome is related to increased risk factors for the disease. However, the author speculates that this may be related to poor immune system performance. Researchers surveyed more than 3,000 men to determine whether there is a predictable association between Y cell loss and Alzheimer's disease. The participants in the experiment came from three long-term studies that can provide regular blood samples. People who spontaneously participate in Alzheimer's disease in Europe, adult men in the Ulapura longitudinal study, and elderly people in the Ulapura prospective vascular study. In the entire study data, the highest incidence of blood cells without the Y chromosome is always more likely to be diagnosed as Alzheimer's disease.

　　Forsberg: "Y chromosome loss is not a 100% prediction. You will get cancer or Alzheimer's disease," he added: In the experiment, 90 men with mutations and no disease can live to old age. However, in the future, blood cells that have lost the Y chromosome may become a new indicator of disease risk factors. Perhaps assessment can make the early detection and treatment of the disease unique.

　　Forsberg, Dumanski and his colleagues studied the effects of Y chromosome deficiency in larger populations and studied in more detail how it harms certain types of cancers and diseases. This is a timetable. They will also observe cell changes caused by the loss of Y chromosomes and how other factors affect different types of blood cells.