糖尿病,动物实验 z-bo 2020-09-22 388

　　"A single injection can last for at least four months." A US research team developed a new drug to control blood sugar levels and achieved success in animal experiments.

　　Researchers said that this study includes hormones naturally present in the human brain, which is expected to help treat diabetes in the future. Related papers were published online in the journal "Natural Medicine". Type 2 diabetes is currently one of the most common diseases, and its incidence is increasing year by year worldwide. It is characterized by abnormally high blood sugar levels, which, if uncontrolled, can cause serious complications and even life-threatening. Previous studies have shown that injecting the hormone fibroblast growth factor 1 (FGF1) into the peripheral blood system of mice has a strong anti-diabetic effect. However, to achieve this goal, large doses of drugs and large doses of injections are required.

　　In a new study, Mike Schwartz of the University of Washington and his team changed their minds and tried to inject hormones directly into the brains of mice and rats with type 2 diabetes. It has been found that a single injection of FGF1 can keep the blood glucose levels of these animals normal for at least 4 months. The researchers said that this treatment is effective in both diet-induced obese mice and genetically-induced obese mice. In addition, this treatment has been found to be effective in genetically induced obese rats.

　　This long-term anti-diabetic effect is not affected by food intake and body weight. This indicates that this improvement in blood glucose levels is not related to weight loss. This study fully demonstrated that the brain can have a powerful influence on systemic blood glucose signals. War Schwartz said that this treatment is currently only effective for rodents with mild diabetes, but this discovery makes it a clinical drug for diabetes because it contains natural hormones in the human brain. This means it can be changed. However, the specific treatment mechanism is still unknown, and further research is needed to answer this question and determine whether FGF1 has side effects.