动物实验,阿尔茨海默氏症 z-bo 2020-09-22 334

　　Protecting the human brain from microbes can cause Alzheimer's disease, which suggests that vaccines can prevent this condition. It has long been believed that Alzheimer's disease is related to the accumulation of amyloid B in amyloid plaques in the brain, but the function of these plaques is unclear. "Do they function in the brain, or do they accumulate like garbage?" asked Rudolf Tangi of Harvard Medical School in the United States.

　　Currently, Tanzi has discovered that these plaques can be used as a defense system against invading pathogens. The Tanji group and Robert Mower group of Massachusetts General Hospital in Boston discovered that amyloid B can act as an antibacterial compound and form part of the human immune system.

　　B-In order to understand whether amyloid can help humans resist microorganisms that try to enter the brain, the research team worked with bacteria that can produce toothpaste similar to humans in mice. Inject into the brain. Therefore, plaques can be formed directly.

　　"Looking at these patches, you can see that there are bacteria in every patch." Tanji said, "Bacteria can form complete patches overnight."

　　This is an infection which shows that it causes plaque formation. These sticky plaques can block or kill bacteria, viruses, and other pathogens, but if they are not removed quickly, they can cause inflammation and entangle other proteins, which can lead to nerve cell death. Accelerate Alzheimer's disease. Disease progression.

　　Samuel Gandhi of the New Uchiyama Hospital in New Zealand said: “Therefore, the viscosity of powdered protein has both advantages and disadvantages.”

　　"This study is very important, showing that amyloid is related to infection," said Brian Walling of the Philadelphia School of Plastic Surgery, Pennsylvania. His research has shown that Chlamydia pneumoniae is a potential factor in the formation of B-amyloid. Other studies have also shown that sporangia virus can induce the formation of B-amyloid. However, so far, there is no good explanation as to why this kind of plaque forms and how it accumulates.

　　The Jacobus Jansen team of Marstricht University found through MRI brain scans that patients with Alzheimer's disease in the early stages of the disease have a highly permeable blood barrier in the brain. This shows that this is because the brain is very vulnerable to pathogens. Jensen said: "The hypothesis of microbiology seems feasible." If infectious agents can prevent plaque formation, vaccines can affect disease groups. Moah said: "In other words, if people can prevent these pathogens with vaccines, then they can prevent subsequent plaque formation."