自闭症 z-bo 2020-09-22 366

　　For a long time, autism has been considered a brain disease. However, a study published on the 9th in the US "Cell" magazine put forward a different view, suggesting that some autism symptoms are related to the defects of the human peripheral nervous system such as limbs and skin.

　　Autism, also known as autism, is a type of mental illness that occurs mostly in adolescents. Symptoms of patients include social disorders, repetitive stereotypes, anxiety, depression, etc. About 95% of patients will experience abnormal sensory perception. The most common example is Hearing and touch are more sensitive than ordinary people. They will cover their ears to avoid making noise and do not like being touched.

　　In the new study, researchers at Harvard University Medical School in the United States first used genetic engineering techniques to create experimental mice containing autism-related gene mutations, but these mutations only occurred in the peripheral sensory nerve cells of the experimental mice. They found that these experiments Rats are extremely sensitive to outside touch.

　　Then, the researchers used common analysis methods to study the anxiety and social status of these experimental mice, and the results showed that they were reluctant to communicate with unfamiliar experimental mice, and their anxiety increased.

　　Harvard Medical School professor David Ginty, who led the research, said in a statement: "A potential hypothesis about autism is that it is just a brain disease, but we found that this is not always the case. "

　　Researchers proposed that mutations in autism-related genes cause major defects in the "volume switch" of peripheral sensory nerve cells in mice, just as the "volume" is adjusted to a high level, causing the mouse's tactile sensation to be amplified, and ultimately causing the mice to suffer Behaving abnormally. This mechanism of action may also be applicable to humans, so the next step they will study how to adjust the above-mentioned "volume switch" back to normal levels through genetic or drug means.