蛋白质,延缓衰老 z-bo 2020-09-23 381

　　Nowadays, people are looking for ways to delay aging. The latest research from the University of Michigan in the United States found that a protein can promote the autophagy activity of cells, thereby resisting aging and diseases caused by free radicals, and injecting hope for people to maintain youth.

　　Research found that free radicals produce a negative effect called oxidative stress in the human body, which is considered to be an important factor leading to aging and disease. Scientists have been looking for ways to combat the effects of this free radical for many years.

　　Research from the University of Michigan found that lysosomes are the core of the cell recycling system and play an important role in repairing damaged and apoptotic cells. When the lysosome "perceives" too much free radicals, it will activate the calcium channels on its surface membrane, which will also stimulate the expression of a variety of genes, and produce more and more powerful lysosomes to eliminate the senescent cells Organelles.

　　The protein calcium channel named MCOLN1 is a lysosomal free radical sensor, which can produce a powerful protective mechanism against the influence of free radicals. Amazingly, this protein is activated due to excessive free radicals, and earlier studies have shown that genetic mutations in this protein can cause a rare neurodegenerative disease.

　　Xu Haoxin, associate professor of molecular, cell and developmental biology at the University of Michigan, said that free radicals are a "double-edged sword" that can cause cell damage and activate protective mechanisms. "If there are chemical compounds that can directly activate this channel, it can reduce the oxidative stress that causes aging and other diseases." Researchers are currently looking for effective such compounds.