寨卡疫苗 z-bo 2020-09-23 329

　　A new research result published in the American "Science" magazine shows that the three new Zika vaccines developed in the United States can effectively protect rhesus monkeys from Zika virus infection without adverse reactions. This paves the way for future human clinical trials. Leveled the road.

　　Previously, these three vaccines have shown preventive effects in mouse experiments. But monkeys are more similar to humans, and are better animal models that can better determine whether the vaccine will achieve the desired effect in humans.

　　Professor Dan Barush of the Beth Israel Deaconess Medical Center, who is in charge of the research, said in a statement: "(3 vaccines) protect rodents and primates from Zika virus infection. Consistent and strong, we are more optimistic about the development of a safe and effective Zika human vaccine."

　　Among these three vaccines, one is developed by the Walter Reed Army Research Institute in a traditional way of inactivating viruses. Eight rhesus monkeys were vaccinated with two doses of this purified inactivated vaccine over two weeks. As a result, they were completely protected from exposure to Zika virus. This vaccine is expected to begin human clinical trials later this year.

　　The researchers also used rhesus monkeys to test two Zika vaccines developed by Harvard University using new methods. One is a DNA (deoxyribonucleic acid) vaccine and the other is a vaccine developed using adenovirus vectors, which can also protect The vaccinated rhesus monkeys are not infected by Zika virus.

　　Half a month ago, two Zika vaccines have been launched in human clinical trials in the United States, one of which was developed by Inovio Pharmaceuticals and the other by the National Institutes of Health.

　　Since last year, Zika virus has been raging in Brazil and other American countries. Most people infected with Zika virus have mild symptoms, but the main concern of the public is that Zika virus infection in pregnant women may cause neonatal microcephaly. There is no effective treatment and vaccine against Zika virus.