心脏病,肝病,糖尿病 z-bo 2020-09-23 364

　　Oranges and other citrus fruits are good for human health because they are rich in vitamins and active ingredients, such as antioxidants, which can help the body maintain health. At present, a group of researchers has found through experiments in mice that for long-term feeding of a Western-style high-fat diet, the active ingredients in citrus fruits can prevent related diseases caused by obesity.

　　The researchers announced the conclusions of the study at the 252nd American Chemical Society (ACS) annual meeting held on Thursday. ACS is the largest scientific association in the world, covering a wide range of scientific topics.

　　"Our research results show that flavanone compounds, a class of antioxidants rich in citrus fruits, can prevent or delay the development of chronic diseases caused by obesity," Paula S. Ferreira said.

　　The U.S. Centers for Disease Control and Prevention stated that currently, more than one-third of adults in the U.S. exhibit obesity characteristics. Obesity can increase the risk of heart disease, liver disease and diabetes. The reason for this phenomenon may be that obesity causes oxidative stress and inflammation, Ferreira said. When humans consume high-fat foods, fat accumulates in the body, and fat cells will produce too much active oxygen, thereby destroying cells. This process is called oxidative stress. The body's antioxidant components usually resist these active oxygen molecules. However, due to the increase of fat cells in obese patients, the content of active oxygen increases, which will exceed the body's ability to withstand active oxygen.

　　Citrus fruits contain a lot of antioxidants, that is, flavanones. Previous studies have shown that the flavanones in citrus can reduce oxidative stress in vitro or in animal models. This study is the first to explore the effect of flavanones in citrus on high-fat diet mice.

　　A research team from the State University of Sao Paulo (UNESP) in Brazil conducted a study on 50 mice and fed them the flavanones in oranges, limes and lemons. Their main concern is hesperidin, eriotoxin and erioviol. The researchers randomly divided the mice into four groups. For one month, they were fed a standard diet, a high-fat diet, a high-fat diet + hesperidin, a high-fat diet + eriotoxin or a high-fat diet + saccharine. Glufol.

　　In the mice of the simple high-fat diet group, the content of cell damage marker-thiobarbituric acid active substance (TBARS) increased. Compared with the mice on the standard diet, the TBARS of the mice in the simple high-fat diet group was lower The content in the blood increased by 80%, and the content in the liver increased by 57%. Compared with mice on a high-fat diet, mice fed with a high-fat diet + hesperidin, a high-fat diet + eriochlor, and a high-fat diet + eriophenol, the TBARS levels in the liver decreased respectively 50%, 57% and 64%. Elycoside and Elycohol also reduced the TBARS content in the blood of mice by 48% and 47%. In addition, hesperidin and saccharol also reduce the accumulation of fat in the liver and slow down the rate of liver damage.

　　"We did not find the effect of citrus flavanones on the body weight of mice," said Dr. Thais B. Cesar. "However, even if the citrus flavanones did not help the mice lose weight successfully, they still exerted a certain oxidative stress effect, helping the mice healthier, less liver damage, and lowering blood lipids and blood sugar levels."

　　Ferreira added, “The study also shows that eating citrus fruits may be beneficial for non-obesity, but people who prefer a high-fat diet can reduce their risk of cardiovascular disease, diabetes, and abdominal obesity.”