糖尿病 z-bo 2020-09-24 364

　　Non-healing of diabetic wounds (diabetic feet) is one of the main complications of diabetic patients. Incurable diabetic wounds may lead to the risk of cuts.

　　East China Normal University announced on the 21st that the latest research result of Layupin Research Group's School of Life Sciences and Shanghai Institute of Regulation Biology Senior Researcher Wuyering is a clinical trial of diabetic wound healing. It is the first time to reveal a new mechanism, revealing that treatment provides new goals and new methods.

　　The research results were published online in the internationally renowned academic journal “Nature” in the nature journal “Nature Communications”, “High blood sugar in diabetes can inhibit the expression of REG3A and cause skin inflammation caused by Toll-like receptor 3. This makes the situation even worse. Bad."

　　Lai Yuping’s research team published an article in the internationally renowned academic journal “Immune” in 2012. Pancreatic regeneration-derived protein REG3A/RegIIIγ can promote skin wound healing by inducing the proliferation of keratinocytes. I reported that four years later, further studies by the research team showed that the pancreatic regeneration source protein REG3A/RegIIIγ is under-expressed in the skin wounds of diabetic patients and diabetic mice, leading to excessive inflammation of diabetic wounds and eventually diabetes. Facts have proved difficult to heal wounds. according to

　　According to the research team, in diabetic skin wounds, hyperglycemia inhibits the expression of REG3A/RegIIIγ and makes it unable to control the inflammatory response, which causes the diabetic wound to continue to produce excess inflammatory factors and heal the wound. Will fail. According to reports, the research results have applied for two invention patents.

　　This research was funded by the China Outstanding Youth Fund and Master Plan, the National Major Research and Development Program, and the Shanghai Science and Technology Commission (basic key). In recent years, researcher Lai Yuping has led a research team that has achieved fruitful results in the field of basic research in skin immunology.