动物造模,果蝇胚胎 z-bo 2020-09-25 388

　　Researchers at the University of Colorado School of Medicine discovered a protein called maricondo in the embryos of fruit flies. This protein can destroy the parent protein. Like the author of the same name, Marie Kondo, who is a fragment consultant, the gene removes unwanted molecules and preserves the tissue of the embryo. The fertilized egg cell is full of maternal molecules that control the early stages of embryonic development. An important stage of development is when the embryo destroys these genetic molecules and begins to produce its own genes. These molecules contain proteins and messenger RNA, the coding instructions for making proteins. Existing studies have confirmed the destruction of messenger RNA, but it is not clear how to destroy the parent protein. According to published in

　　According to the research scientist on eLife, researchers have discovered the existence of Marie Kondo protein using the technique of screening 150 possible enzymes. This method allows you to observe the destruction of the parent protein through a fluorescence microscope. After several months of work, they identified this enzyme and named it "Marie Condo". Olivia Lisland, assistant professor of biochemistry and molecular genetics at the University of Colorado School of Medicine, said: "Usually, when we talk about removing maternal gene products, we tend to focus on the coding information of mRNA or protein. ." and the co-author of the study. "However, we are talking about the destruction of the protein itself. Rarely. One of the significance of our research is that in the early stages of development, the destruction of maternal protein can be controlled more strictly than we thought."

　　Issland discovered this. Opened the door for further study of embryonic protein destruction. "I started to study these proteins because they regulate RNA. Now that any other protein is destroyed, how protein destruction affects not only small animals but also the early development of other animals."