动物造模 z-bo 2020-09-26 310

　　A few days ago, researchers from the Harvard Stem Cell Institute (HSCI) published two papers in the journal Science. The protein used to make an old dysfunctional heart look like a young and healthy mouse heart. . I confirmed that I found it to improve brain and skeletal muscle function in old mice in a similar way. Professors Amy Wagers and Leeubin of Harvard University's Department of Stem Cell Regeneration Biology are the senior authors of these two papers. They report that injection of a protein called GDF11 (GDF11 is found in mice and humans) can improve the exercise capacity of 70-year-old mice and improve the function of the olfactory area in the brain of aging mice. They can recognize smells like mice. They said that if something unexpected happens, they hope to extend GDF11 to human clinical trials within 3-5 years.

　　These two studies examined the effects of GDF11 in two ways. In the first study, the researchers used a so-called joint living system, which connects two mice through surgery, while the blood of the young mice circulates through the old mice. The second study was to inject GDF11 into old mice. In previous studies, one of the authors of the two papers, Wagers and Richard Lee of Brigham and Women's Hospital, confirmed that GDF11 is sufficient to reverse certain characteristics of cardiac aging.

　　Doug Melton, deputy director of the Harvard Stames Institute, said: "This is the most exciting discovery from stem cell science, and the most primitive experiment. It provides us with the hope of a healthier future. We all know why we are young when we are young. I want to think faster and stronger. These two unusual and exciting research papers point out the actually possible answer: when we are young, our GDF11 protein levels are high. At least this does not seem to be a problem. In some animals, GDF11 has an amazing ability to restore aging muscle and brain function. The indicated natural concentration is much higher. So far, the increase in GDF11 levels in aged mice has been improved. So far, the function of each organ system has been studied.

　　14 years ago, when Wagers was a PhD researcher at Stanford University, he first conducted research using the combined life system of mice. She and her colleagues observed that the blood of young mice circulated in young mice, which seemed to affect the injury after injury. Muscle repair produces several regenerative effects. In 2013, she and Richard Lee reported in another paper that when exposed to the blood of young mice, the enlargement and weakening of the heart of old mice will return to its young size, and The function is improved. Then, they worked with a Colorado company to confirm that GDF11 in the blood was clearly responsible for this regenerative effect. This makes people hope that GDF11 may be a treatment for dilated heart failure, which is an irreversible fatal disease in the elderly.

　　The punter said: "The previous study seems to be heart-specific, but new research shows that it is activated in multiple organs and cell types." In a new study, GDF11 appears to be in old mice Happened in. It has been proven to help restore muscle damage. Restored and improved the performance of running and grip tests. Rubin said: "It is well known that some of the brains of old mice are very poor, with reduced neurogenesis and impaired cognitive ability."

　　In a new study, researchers found an increase in neural stem cells in the brain. And confirmed that blood vessel development increased. .. The results of 3D brain reconstruction and magnetic resonance imaging (MRI) in mice showed that there are more new blood vessels and more blood flow, both of which are usually associated with young and healthy brain tissue. it is. Rubin said: "Young mice smell very good. When I tested young mice, I avoided the smell of peppermint, but avoided the larger smell, but used the blood of young and elderly patients treated with GDF11. ." I avoided contact. I can be a mouse. "

　　Rubin said: "We believe that GDF11 improves blood vessels and blood flow and is related to increased neurogenesis. GDF11 should have a wide range of effects on other parts of the brain. At least in principle, the above. There should be a way to use protein to reverse some The method of aging deterioration, GDF11 or a molecule similar to GDF11 itself may be able to reverse the damage of aging, if all goes well, GDF11 or then, the drug developed is very valuable for Alzheimer's disease."

　　Wagers, the two research teams talked with venture capital groups before extending GDF11 to human experiments and other necessary preclinical studies. We believe we have the funds to carry out this work. He said: "There is no doubt that some combination of this research and other studies will translate into clinical trials and treatments. Of course, this is just a bet."