动物实验 z-bo 2020-09-26 432

　　Recently, researchers have made great strides in how zebrafish eels control the absorption and outflow of sodium ions. This new discovery will help us better understand the main functions of the human kidney. Published the results of a joint study between York Clinic and Tokyo Institute of Technology in May. Researchers have discovered a protein that is responsible for ion exchange in the g structure of zebrafish. Specifically, I studied and explained the Na +/H + (sodium/hydrogen) exchanger (named NHE3), which plays an important role in controlling the passage of sodium and hydrogen ions through the heat sink. The researchers also directly showed that NHE3 can also play a role in the Na +/NH4 + (sodium/ammonium) exchange function.

　　May York Clinic physiologist Dr. Michaelomero explained: The results of this study are important because fish tend to imitate human processes. This is true physical beauty. The working process of many organs is very similar. Studies have shown that this protein absorbs sodium ions from the formed urine, while "discarding" waste, thereby keeping the body in balance and maintaining an energy-saving system.

　　According to the researchers, the same NHE3 protein performs similar functions in the intestine, pancreas, liver, lung and reproductive system. Zebrafish use eels as a transportation system. Sodium ions are recycled nutrients, and ammonium is a waste product that is removed. This is an important process that allows zebrafish to extract sodium ions from fresh water. In humans, NHE3 participates in the control system of acid waste in the kidney, but in humans, this process is not well analyzed. In the human kidney, this acidic waste management process is part of the "ammonia production" process and requires the first part of the renal tubules (proximal tubules) to transport ammonia/ammonium. Physiologically, NHE3 is thought to be able to perform the Na +/NH4 + exchange function, but this has not been experimentally confirmed. The increase in ammonia production and the absorption of sodium bicarbonate by the kidneys are partly controlled by the renin-angiotensin-aldosterone system (RAAS). This means that this work can improve the understanding of human hypertension. Researchers say their findings in zebrafish fish may be a clue or starting point for analyzing human kidney function. The researchers said that they hope to continue related work in other species and eventually explain this process further in the human body.