动物实验,祛斑模型 z-bo 2020-09-28 553

　　Human skin color is related to the type and quantity of skin pigment. Melanin has the greatest impact on skin color. Melanin is formed in melanocytes at the base of the epidermis. In this process, melanin tyrosine produces dopa and dopaquinone under the action of tyrosinase, and finally forms melanin. Melanin migrates to basal cells, is carried in the entire epidermis along with the migration of epidermal cells, and is eventually lost due to the shedding of keratinocytes. Tyrosinase is an important enzyme in the production of melanin, it regulates the production of melanin, and its degree of activity plays a major role in pigmentation.

　　The in vitro melanosome model does not consider the influence of other adjacent cells in the body on the melanosome. The biological behavior of cultured melanosomes is highly dependent on the actions of a series of cytokines that are significantly different from the internal environment. The animal model used to study the process of melanin production in the body has complicated experimental procedures and a long experimental period. As a biological model, zebrafish provides a useful tool for studying the regulation mechanism of pigment cells. Zebrafish neurochromatin cells include melanocytes, yellow pigment cells and halogen chromatin cells. The embryonic development process of zebrafish proceeds in vitro, and several dark bands formed by melanocytes and halogenated chromatin cells are formed within about 24 hours. The zebrafish model provides an advantageous way to study the development and differentiation of pigment cells and the etiology of pigment diseases. HuanteBio has successfully established a buckling remover screening model to evaluate and screen zebrafish for the treatment of pigmented diseases or melanoma.