动物实验,骨髓移植系统 z-bo 2020-09-28 397

　　An artificially bred adult zebrafish used as a new and competitive bone marrow transplant system.

　　"Hematopoietic stem progenitor cell" (HSPC) transplantation (by transfusion of bone marrow or peripheral blood progenitor cells) is clinically used to treat certain cancers and blood and immune system diseases, but how do I transplant HSPC? Little is known about transplant recipients. LeonardZon and his colleagues have established a competitive bone marrow transplantation system with adult zebrafish. In this system, the status of transplantation is measured by in vivo fluorescence imaging of the kidney (as artificial blood spots). This model is used to filter "port enhancement" activities.

　　"Epoxydocosatetraenoic acid" (EET) (11,12-EET and 14,15-EET) can enhance transplantation by activating the expression program mediated by the transcription factor Runx1. It is different from HSPC. This activity of EET is retained in mice, indicating that EET may have the clinical potential to promote bone marrow transplantation.