动物实验,肌肉营养不良 z-bo 2020-09-28 346

　　This is like an incurable disease caused by genetic mutations and affected by the loss of dystrophin in muscle cells. To better understand the effects of this protein loss, researchers at Salisbury University and King's College London studied human dystrophin in zebrafish embryonic muscle cells. The researchers used a new observation method developed by Sairee University to successfully observe the movement of dystrophin in living cells. It is hoped that scientists can better understand the role of dystrophin in real-time observation of protein in the human body. Ultimately, this will help the development of future treatments.

　　Muscular dystrophy is an incurable genetic disease that causes more muscle atrophy, paralysis and premature death,” explains Dr. Richard Lee of the University of Surrey.

　　"Research shows that patients with this disease lack dystrophin, but we still don't know why this protein is so important to our body." He added. A new method of observing dystrophin can avoid living cells that have never been done before. Using this new method, colleagues at King's College London can see how dystrophin works. People are very excited because this terrible disease can be treated. "

　　"What they see is that dystrophins are on average 30 times larger than protein, but they are very easy to move. I think this is work, including muscle cell skills. Now, scientists will be able to observe it at work and better Understand the function of dystrophin in our body and our understanding of this gene therapy."

　　zebrafish are transparent like embryos, so by adding fluorescently labeled dystrophin molecules, you can see that the muscle cells of zebrafish are working.

　　"The next step of this research is to use this new method to observe different variants of dystrophin that are known to cause different degrees of disease, and to try to understand the relationship between these variants and disease. From there, scientists can Nearly better, smaller versions of proteins are used in gene therapy."