动物实验,益生菌治疗 z-bo 2020-09-28 423

　　The intestinal flora plays an important role in affecting host metabolism, physiological level, nutrient absorption, lipid metabolism and growth. Changes in the composition or interaction of the gut microbial community are associated with several intestinal diseases, including cancer and metabolic diseases. The research focused on the treatment and restoration of the diversity of intestinal flora and found that the use of probiotics to adjust the microbial composition can also improve the host's nutritional metabolism and energy balance.

　　Using a mouse model of non-obese diabetes (NOD), it was found that changing the gut microbial community and metabolism may change the host's glucose metabolism, leading to the development of type 1 diabetes. The use of the Drosophila model also proves that the genotype of the host is closely related to plant-like animals, because it can regulate signaling pathways, including triglyceride and glucose metabolism. The zebrafish model showed that the use of probiotics to regulate the intestinal flora involved in the down-regulation of cholesterol and triglyceride metabolism (FIT2, agpat4, DGAT2, mgll, HNF4A, SCAP and CCK) genes. It has been proven that it can regulate the lipid metabolism of the host. In order to assess the beneficial effects of probiotic lactic acid bacteria on appetite and glucose metabolism in the zebrafish model, researchers continuously evaluated the zebrafish gastrointestinal (GI) flora after exposure to probiotics.

　　is involved in the regulation of appetite, sugar metabolism, overall biological blood sugar level and the level of gene transcription of food intake. After 8 days of exposure of zebrafish juveniles to Bacillus subtilis, the high-throughput sequence showed that probiotics have the ability to regulate the gastrointestinal microenvironment. Changes in the intestinal microenvironment can lead to up-regulation of genes related to lower glucose levels, thereby reducing appetite and human glucose levels. These results highlight the ability of probiotics to regulate the gut microbial community and provide insights into how probiotic interactions regulate glucose metabolism and appetite regulation related gene networks. It also shows that Lactobacillus has an effect on food intake and glucose tolerance.