动物实验,彩虹斑马鱼 z-bo 2020-09-28 390

　　Researchers have recently developed a genetically modified zebrafish that can cause the skin to fluoresce in thousands of colors. This allows scientists to track the behavior of hundreds of individual cells in real time and understand what happens when the skin is damaged. .. Kenneth Boss of Duke University at Duke University in North Carolina, who led the study, said: "This is a particularly beautiful fish." The researchers published in the latest issue of the journal Developmental Cell. The results of this research. according to

　　Researchers said that their idea was originally based on the "brain rainbow" technology announced in 2007, in which nerve cells express mixed fluorescent proteins through genetic engineering to form different cells. Generate various color combinations that can be represented randomly.

　　In zebrafish, skin cells express proteins through genetic engineering. This same concept is called "skin rainbow". Fluorescent cells are trapped in the outer layer of zebrafish skin and cover the entire body surface including corneal tissue. Based on the number of combinations of red, green and blue proteins that these fluorescent cells can express, a single cell is expected to emit any color of about 5000 different color combinations. In fact, only about 70 colors can be clearly recognized under a microscope. However, this is enough to make most units "barcode" and "encode" differently from adjacent units. By tracking hundreds of individual skin cells, researchers will be able to study how the skin recovers from wear and tear, such as wear and tear, in real time. For example, scientists discovered that when cutting a fin, cells use three different processes to cover the regenerated tissue with skin. The skin cells migrated from the nearby area also covered the new tissue. New skin cells are produced, and the number of some cells is also greatly increased.

　　Pos said: "This is a very interesting study." "I don't know what will happen, but there is a good way to observe it."

　　Zebrafish's body is long and slight. Fusiform, small head, slightly pointed, short snout. The whole body is covered with dark blue stripes similar to zebras, alternately arranged with silver white or golden yellow stripes. When swimming in groups in an aquarium, it is called a zebrafish because it resembles the galloping zebras on the African grasslands. Zebrafish and human genes have a high degree of homology of 87%, and their superiority as a model organism is excellent, and the experimental results are applicable to humans in most cases. It is usually used to monitor the water environment. Internationally, the use of zebrafish model organisms is gradually expanding, and it extends to the development of various biological systems (nervous system, immune system, cardiovascular system, reproductive system, etc.), functions and diseases (neurodegenerative diseases, etc.). , Hereditary cardiovascular diseases, diabetes, etc.), applied to large-scale new drug screening of small molecule compounds.