斑马鱼,动物模型,内分泌干扰物 z-bo 2020-09-29 376

　　Water is essential for human survival, and water quality has always been the focus of public health authorities, because water may contain a variety of environmental pollutants, including endocrine destructive chemicals (EDC). Endocrine-destroying chemicals are a group of potentially harmful substances, composed of natural and synthetic chemicals, which can mimic endogenous hormones and interfere with their biosynthesis, metabolism and normal functions. Possible common examples are bisphenol A, triclosan, phthalates, lead, mercury, nickel and PCB.

　　fish are particularly sensitive to the effects of EDC and are used as a research model to study the potential effects of these chemicals on humans. In a joint review conducted by Purdue University and the University of Cartagena, Columbia, the research team recommended the use of zebrafish as a predictive model for toxicological genomics tools such as microarrays and whole-genome test sequences. Achieved the impact of EDC on humans. This method is feasible because it significantly changes the expression of zebrafish genes after exposure to EDC. This is very similar to what you see in humans. In addition, the gland system of zebrafish is similar to that of humans, so this fish model is very suitable for studying changes in the endocrine system.

　　According to the author, egg yolk protein and aromatase phosphorylation of P450 are important genes that can be monitored in zebrafish, and the presence of EDC in water samples can be detected, especially in concentrated polymers related to the environment. Toxicological genomics tools provide EDC with the possibility of discovering new mechanisms that change the reproductive status of zebrafish. It can be used for safety testing before the new product is released. This possibility is huge. The current goal is to find a new toxicity marker and use it as a new bridge between EDC and common human diseases.