动物实验,肥胖,肌肉功能下降 z-bo 2020-09-29 375

　　Obesity affects muscle phenotype, thereby limiting exercise and energy expenditure. Weight loss is the most common and intuitive intervention for obesity, but it is not clear whether weight loss can offset the effect of obesity on muscle function?

　　Recently, an academic from the University of Sydney passed a small test to prove whether the phenotypic changes in muscle metabolism and contraction caused by weight loss can be reversed.

　　Researchers use zebrafish (Daniolerio) to reduce energy metabolism, exercise performance, muscle isometric strength, work cycle output and muscle, lean fish, diet-induced obesity fish, and body weight. We compared fish that lost weight after weight gain. For more information (such as globulin heavy chain composition), use zebrafish to test the following hypotheses: a) Obesity reduces metabolism and creatine citrate synthase activity due to mitochondrial dysfunction; b Obesity reduces isolated muscle output ; Researchers predict that these changes in contractile function are related to decreased exercise capacity and changes in the composition of myosin heavy chains. c) Obesity, metabolic changes caused by skeletal muscle and exercise phenotype can be reversed to weight loss. The result is an increase in resting metabolic rate (p\u003c0.001) and a decrease in maximum metabolic rate (p = 0.030) due to obesity, and these changes can be reversed by weight loss citric acid. It was found that it had nothing to do with changes in creatine synthase activity. In contrast, exercise performance caused by obesity (p = 0.0034), isometric stress of isolated muscles (p = 0.01), working circuit output (p\u003c0.001), relaxation rate (p = 0.012), etc. cut back. Lost due to weight loss. Similarly, obesity leads to lower levels of myosin heavy chain, and weight loss does not reverse to the rapid transition of myosin heavy chain.

　　Therefore, you can only draw one conclusion. But losing weight is actually just "weight loss" and your body will get worse! The changes in exercise performance and muscle contraction caused by obesity can only be improved by exercise.