动物实验,PM2.5,冬虫夏草 z-bo 2020-09-29 871

　　In the early days, the Huante biology research team used zebrafish technology to help lilies and other traditional Chinese herbal medicines release pm2.5 nanoparticles, or release them to organisms through atomization. We have confirmed that the damage caused has been reduced to a certain extent. The application of zebrafish technology in clinical research of medicines and health foods has passed the evaluation of Hangzhou expert group.

　　Recently, the Institute of Toxicology and Pharmacology of the Academy of Military Medical Sciences and the State Key Management Laboratory of Traditional Chinese Medicine of Guangdong Dongyang Sunshine Pharmaceutical Co., Ltd. have found that Cordyceps has an effect on the excretion of PM2.5 ultrafine particles in the body. About the cooperation with Hongzhou Huate Biological Technology Co., Ltd. This mechanism has been discussed and published in the 2017 "Food Science and Technology".

　　Cordyceps is a rare Chinese medicine in China. Modern clinical and pharmacological studies have shown that Cordyceps can improve respiratory and cardiovascular diseases and enhance immune function. Currently, there is no research on the effect of Cordyceps sinensis on the release of PM2.5 particles. Therefore, this research is also very meaningful. The researchers first created a zebrafish PM2.5 ultrafine particle excretion model by injecting nano-activated carbon particles into the zebrafish yolk sac. After the intervention of cultivation and wild cordycepin, we observed the effect of excretion of nanoparticles from zebrafish into the intestines. influences.

　　Next, we established a zebrafish PM2.5 ultrafine phagocytosis model using intravenous injection of nano-activated carbon. After the intervention of cultivation and wild Cordyceps, an effect on the ability of zebrafish macrophages to engulf PM2.5 was observed.

　　Finally, we will use the method of intravenous injection of ink to test the effect of cultured Cordyceps sinensis and wild Cordyceps sinensis on the dietary function of mouse macrophages. The results showed that compared with the model group, both cultivated and wild Cordyceps had a significant effect on promoting the excretion of nanoparticles into the intestines (P\u003c0.05 or P\u003c0.01) I found it. Significantly improve the eating habits index of mice (P\u003c0.05 or P\u003c0.01). Experiments have shown that both cultivated Cordyceps and wild Cordyceps can promote the excretion of PM2.5 ultrafine particles, and this mechanism may be related to the enhanced phagocytosis of macrophages.