HIV感染,新细胞疗法 z-bo 2020-09-29 354

　　Antiretroviral therapy (ART) aims to prevent HIV infection, but it cannot eliminate HIV in the body. The reservoir is the source of lifelong HIV infection. Two recently published studies show that it is hoped that new methods of preventing HIV infection of cells can eliminate or permanently inhibit the activity of "storage" cells. The first drug requires the energy needed to produce HIV in the reservoir cells, while the second drug can permanently inhibit the spark that ignites the fuel and reservoir. Inhibit the activation of potentially HIV-infected cells. A research team from the Pasteur Institute in Paris, France found that the key to the susceptibility of T cells to infection depends on their metabolic activity, the energy required and the conversion rate of energy such as glucose. Studies have shown that metabolic rate is related to T cell types. Energy-intensive cells are susceptible to infection and can be used as targets for new drugs. A "fake" inactive glucose feeder cell called "2-DG" is used to slow down cell metabolism. It can selectively kill HIV-infected cells in laboratory petri dishes, even cells that did not activate HIV-producing cells. One of the advantages of 2-DG is that it is cheap to manufacture and can be used for cancer research.

　　In another study, a team at the University of Pittsburgh screened several compounds that might prevent potential HIV-1 activation. HIV storage cells are activated to produce HIV. If cell activation is inhibited, even if antiretroviral therapy is stopped, HIV infection can be avoided, the so-called functional cure. This potential treatment strategy is called "blocking and locking" by researchers, and it relies on inhibiting HIV reservoir cells rather than a "kick and kill" method based on the activation of reservoir cells. The research team screened several compounds that inhibit activation from a chemical library composed of 418 "kinase inhibitors." Among them, PF-3758309 and other molecules can block cell activation, and its inhibitory activation dose is much lower than the toxic dose. Maybe you will find a medicine that can permanently control HIV infection.