动物实验,肠道菌群移植,肠道菌群 z-bo 2020-09-30 320

　　The intestinal flora is becoming an important regulator of various metabolic, immune and neuroendocrine pathways. Intestinal microbial diseases are related to major diseases such as obesity, type 2 diabetes, cardiovascular disease, non-alcoholic fatty acid liver disease and cancer, but their exact role in aging remains unclear.

　　Recently, scientists at the University of Oviedo in Spain have studied this problem and discovered a link between aging and the gut microflora. In this study, the authors found that two different mouse models of premature aging have characteristics of intestinal diseases. Changes include increased abundance of Proteus and cyanobacteria, and decreased abundance of vulgar microbes. Consistent with these findings, the researchers also found that human patients with progeria also exhibit intestinal diseases. The vulgar microbes in the intestines of long-lived people have increased significantly, while protein deformation has decreased significantly.

　　The researchers also found that in the two mouse models of premature aging, the transplantation of wild-type mouse fecal flora can prolong healthy life and prolong life, and the transplantation of Akkermansia mucinifila, a viruculum microbial mucus alone, has beneficial effects. . I found enough. In addition, through metabonomic analysis of the contents of intestinal obstruction, the researchers found that the restoration of secondary bile acids may be a beneficial mechanism for rebuilding a healthy microbiota. Therefore, the results of this study indicate that it is beneficial to correct intestinal diseases associated with accelerated aging. This indicates that there is a link between aging and the gut microflora.