CAR-T细胞,HIV z-bo 2020-09-30 377

　　Recently, researchers from the Gladstone Institute of Virology and Immunology and other scientific research institutes have used transformable CAR-T cells to attack potential HIV and established an indication called “Using transformable CAR-T Cells attack the latent HIV, which is a highly applicable killing platform." We have published an article about this unit. Powerful virus scanning platform.

　　Currently, in order to reduce the potential for HIV, you must first activate the host cells containing the virus to make them visible to the immune system. The second is to kill these cells and reduce the virus pool. Due to cell exhaustion and the evolution of anti-CTL viruses, endogenous cytotoxic T lymphocytes (CTL) may be lacking. The researchers designed a CTL-based universal chimeric antigen receptor T cell (CAR-T) platform. Here, CTL is designed to bind to multiple anti-HIV antibodies. On this platform, convertible CAR-T cells have anti-HIV antibodies, which can effectively kill HIV-infected CD4 T cells in the blood, tonsils and spleen, but cannot kill uninfected CD4 T cells. .. Using antiretroviral methods, transformable CAR-T cells can kill more than 50% of the inducible virus pool in the blood of HIV-infected persons within 48 hours. In this study, the convertible CAR-T cell platform can be used in combination with various anti-HIV antibodies, thereby increasing the scope of application and control, and becoming a potential tool for killing potential HIV libraries.