癌细胞抗药性 z-bo 2020-09-30 364

　　Drug resistance has always been the main challenge we face in the fight between humans and cancer. In the latest research report published in the international journal Nature Communications, scientists at the University of California and other institutions may find that new methods can overcome resistance. Obstacles to cancer drug resistance; researchers are dead cells. We have revealed a special mechanism that promotes diseased cells to obtain nutrients by cleaning their debris. Relevant research may provide researchers with new target points to support the development of anti-cancer strategies.

　　Researcher Aimee Edinger said that cancer cells need a lot of nutrients. Chemotherapy and other DNA damage therapies can drive tumor cells to stimulate cell metabolism and perform the necessary repairs to make them survive and grow. In this way, you can target your DNA. Metabolism usually takes a long time to work, but in almost all patients, tumor cells become resistant and treatment is ineffective. In the process of studying this problem, the researchers noticed a process called giant pinocytosis. This can encourage cancer cells that desperately need nutrition to find dead cancer cells in the tumor and use them as food to make them grow. Tumors contain a large number of dead cells because the blood supply in the tumor is abnormal and promotes the death of many cancer cells. Using the above removal mechanism, cancer cells can acquire amino acids, sugars, lipids and nucleotides to grow.

　　According to the researchers, the process of developing breast cancer resistance in the process of giant pinocytosis may not have been paid attention to by many scientists. The same process occurs in the pancreas and prostate. Finally, Dr. Edinger said that blocking the effect of giant pinocytosis has effectively treated a variety of cancers, and that it can also bypass the treatment and activate cancer cells. He said it could be treated. Researchers are currently screening for better biomarkers in clinical drug trials, which may help improve patients. Regarding the therapeutic response of multiple concomitant drugs, the results of this article provided a strong theoretical basis for later scientists to develop new drugs aimed at blocking the effect of giant pinocytosis.