CAR-T细胞 z-bo 2020-10-07 309

　　According to a new study, among children and adolescents who received CD19 chimeric antigen receptor (CAR) T cells (CAR-T) injections, the infection rate increased in the first month after treatment and then decreased.

　　Dr. Surabhi B.Vora of the University of Washington in Seattle, USA, and his colleagues performed CD19CAR-T cell therapy on 83 patients under the age of 26 from 2014 to 2017. I have seen it. They calculated the number of people at risk of infection 90 days before treatment, 0-28 days after treatment, and every 29-90 days after treatment. These researchers found that 98% of patients had refractory or relapsed acute lymphoblastic leukemia. In the 90 days before treatment, 54% of patients developed infection (infection density 1.23), and within 28 days after treatment, 40% of patients developed infection (infection density 2.89). 29-90 days after treatment, the infection density dropped to 0.55, and most infections were bacterial or respiratory virus infections (39% and 43%, respectively). In previous hematopoietic cell transplantation, immunoglobulin G (IgG) levels of 400 mg/dL and lymphocyte depletion other than cyclophosphamide and fludarabine were risk factors related to pretreatment infection; more serious cytokines Release syndrome and IgG\400mg/dL are risk factors related to infection after treatment.