大脑蛋白质,肥胖,酰基辅酶A结合蛋白a z-bo 2020-10-07 322

　　Whether you exercise more or diet, the relationship between weight control and the brain is much closer than you think. In a study published in the Journal of Clinical Research, researchers at the Research Center of the University Hospital of Montreal (CRCHUM) found that acyl-CoA-binding protein a (ACBP) directly affects the neurons of mice and causes rodents, the first discovery And humans can maintain a healthy weight.

　　CRCHUM researcher Thierry Alquier is the first author of the study. His team discovered that this protein can cause stellate cells (cells that support nerve function) to change fatty acids and lipids in the blood. I found that it can spread to neurons. This important information enables the brain to regulate food intake and energy expenditure, and ultimately control the weight of the owner. "In collaboration with colleagues from the Newtree Institute of Neurology at the University of Bordeaux, the protodermal melanocorticoid (POMC) neurons that reduce food intake are produced in a specific area of the brain (the arcuate nucleus of the hypothalamus). We have proven that it is a Protein. ACBP’s stellate cells are closely related,” said Thierry Archie, associate professor at the University of Montreal.

　　This area of the hypothalamus is essential for controlling diet and metabolism. This area of the hypothalamus contains two groups of neurons that have opposite functions when activated: the first group leads to increased food intake; the second group of animal and human POMC neurons share. The group promoted a reduction in food intake and an increase in energy consumption.

　　"Gene mutations explain 5% to 10% of obesity cases," Alquier said. "Most of these cases are related to the destruction of this neural pathway, which is usually called the adrenal cortex pathway. We have already observed that the loss of the ACBP gene in the arch nucleus stellate cells promotes obesity. However, in transgenic obese mice The daily injection of ACBP can reduce food intake and weight loss by 5% within 5 days, which is a type of POMC neuron.

　　However, researchers should be cautious when applying this discovery to humans. This research is still in the basic research stage and is being carried out in the mouse laboratory.

　　The World Health Organization recognizes that obesity is a global public health problem. Obesity is a major risk factor for type 2 diabetes, cardiovascular disease, and certain chronic diseases (such as certain cancers, musculoskeletal diseases, and premature death).